Pilot Program:

Funding for Development of Novel Clinical and Translational Methodologies

Pilot funding for the development of novel clinical and translational methodologies will be made available to all of Yale’s faculty.  We plan to offer ~ 3 grants.  Each award will be up to $25,000.

Scope:

Applications should request seed money to explore novel methods that will enhance clinical and translational research studies and create new funding opportunities for Yale scientists.

Eligibility requirements:

The only requirement is that the applicant is Yale faculty.

Funding available and years of support: 

Funding will be available for up to $25,000 in total costs for a 12-month period beginning July 1, 2008.  Proposals in the $12-15,000 range are particularly encouraged in order to fund as many worthy proposals as possible.  Support may be provided for salary, supplies, and other research-related expenses; funds may not be used to purchase equipment or for travel expenses (except as needed to reimburse clinical study participants).  Award is not renewable or transferable.

Review Process: 

Important elements in the review process will be:

• Scientific merit:  Is the research proposed important and innovative? 
• Funding:  Is the research likely to establish the basis and rationale for a larger project and to result in a successful application for extramural funding by this larger project?  Could the research be accomplished without funds from this RFA?

Submission:

Candidates MUST use the application and budget templates.  Element of the application are included below:

Submission Process

Application Form

Budget Template

Selection criteria:

Criteria for selection include innovation and potential to provide new opportunities for clinical and translational research.  Preference will be given to methods that would support interdisciplinary projects.  Proposals will be evaluated for compatibility with the YCCI mission, merit, and feasibility for conduct. Junior investigators new to translational research are particularly encouraged to apply. Established investigators interested in developing a new area of clinical or translational research are also eligible for support.

Additional Requirements:

The abstracts and names of all investigators funded through the Pilot and Collaborative Studies Program will be posted on the national CTSA website.  In addition, all investigators must provide a progress report to the YCCI, and acknowledge the YCCI CTSA base operating grant in any publications resulting from the supported studies.  The YCCI also requires that results of studies supported through the program be posted on the Yale YCCI website once the data have been published. 

2007 Novel Methods Clinical & Translational Awardees

PI	Department	Project	Amount Funded	Award Dates
Douglas Befroy	Internal Medicine-Endo	Implementation of FAST-MRS to Study Mitochondrial Function at 4T	$19,972	10/1/07-9/30/08
Demetrios Braddock	Pathology	Validation of Bithionol, Hexachlorophene & Merbromin as a Chemotherapeutic Agents in the treatment of Ovarian Carcinoma & Melanoma	$24,500	10/1/07-9/30/08
Chirag Parikh	Nephrology	Identifying Acute Tubular Necrosis in Patients with Cirrhosis and Renal Dysfunction	$20,000	10/1/07-9/30/08
Total Novel Methods Clinical & Translational			$64,472