Biospecimen Management

For investigators who need assistance with acquiring tissue specimens for their biobanks, the Yale Pathology Tissue Services (YPTS) is a great resource. Under the direction of David L. Rimm, MD, PhD, YPTS is a well-established pathology-based Central Tissue Resource Lab that provides comprehensive tissue-related services and material for investigators. This resource is dedicated to providing the maximum amount and quality of human tissue for research without affecting diagnostic quality, accuracy, and safety related to patients. The four lab groups, Clinical Trial Tissue Services (CTTS), Developmental Histology (DH), Specialized Translational Services (STS), and Tissue Procurement and Distribution (TPD) will be able to assist investigators with most tissue-based research requests. For more information on services provided by YPTS, visit their website here.

Under the direction of Kevan Herold, MD, YCCI’s deputy director of translational science and professor of immunobiology and of medicine (endocrinology), YCCI’s biospecimen unit can help investigators manage biospecimens electronically. YCCI has staff members to help investigators manage biospecimens electronically and develop case report forms for specimen collection. Staff can help investigators make the most of OnCore’s Biospecimen Management (BSM) module, which keeps track of sample inventory, collection, processing, storage, and distribution in a secure environment. BSM is paired with a Unified Registries Management (URM) module that uses electronic case report forms for research subject registries and is able to track clinical outcomes. Implemented in 2013, this service provides easy access to data while storing them in a HIPAA-secure environment. Additional security features help investigators manage specimens associated with multicenter trials by allowing collaborating institutions to enter data into a single system through restricted-access portals. Investigators are now able to utilize easy-to-use standard reports to better track key characteristics of their sample collections and inventory; or they can work with YCCI staff for more comprehensive needs.

Investigators with an IRB-approved protocol for biobanking, clinical research involving specimen collection, or a patient registry and data manager who can collaborate with YCCI data analysts to customize their databases are encouraged to utilize the URM and/or BSM systems. Contact Helen Seow, PhD, YCCI’s associate director of research administration at helen.seow@yale.edu.