Yale School of Medicine

Major Department or Entity

Major Department or Entity

Yale Center for Clinical Investigation
2 Church St. South
New Haven, CT 06519
Tel: 203.785.3482
Fax: 203.737.2480

Core Laboratory and Other Lab Services

YCCI’s core laboratory Services provide an investigator with access to selected analyses and procedures that might otherwise be unavailable or too expensive.

The lab provides more than 40 different tests. In addition to offering point-of-care glucose (clia license), lactate and ethanol measurements, the lab measures a variety of hormones, substrates and cytokines. The sample analytic unit includes radioactive assays, elisa, hplc and substrate analysis.

The lab operates Monday through Friday from 7:30 a.m. to 5:00 p.m., and is also open two to three evenings a week and one weekend per month.

Researchers who would like to consult with this service should contact Theresa Katz at 785-6335 or theresa.katz@yale.edu.

Sample Processing Core

Hours of operation: Monday – Friday (7:30am - 5pm)
In addition, the lab is usually open evenings 2-3 times each week and one weekend each month.

  • Refrigerated centrifugation is standard
  • Freezer storage options to –70*
  • Computerized labeling
  • Assistance with sample packaging for shipping

Hormone Core

A large facility capable of analyzing a variety of hormones utilizing RIA, IRMA, and ELISA techniques. Support focuses on assays not readily available in clinical laboratories or large batches of samples too expensive to send to routine hospital facilities.

Substrate Core

An automated laboratory capable of measuring most routine substrates and clinical enzymes utilizing an Alfa-Wasserman ACE analyzer. Also suited to automating the measurement of research compounds using UV/VIS spectrophotometry.

ELISA Core

Our newest core is capable of analyzing most cytokines and tissue markers using a UV/VIS plate reader. The analysis kits for many newly discovered hormones also utilize the ELISA technique making this an important resource to investigators.

HPLC Core

A small highly specialized area focusing on plasma catecholamine measurements and plasma free amino acid chromatography.

Immune Monitoring Core Facility

The Immune Monitoring Core Facility provides a core resource for clinical and translational research protocols that involve immunotherapy and/or that affect the human immune system. Consultation regarding optimal immunologic assessment, assay development for innovative evaluation approaches, and provision of assays on a fee-for-service basis are all parts of our mission.

MRI Core

The Magnetic Resonance Research Center (MRRC) in collaboration with the YCCI provides supported access to this MRI resource. All systems have state-of-the-art electronics capable of performing the full range of MRS and MRI sequences including: 13C, 31P, and 1H MRS; spectral eliciting; short echo acquisition; and 3/4D spectroscopic imaging. The YCCI also provides nursing support and sample processing to facilitate patient safety and data collection.

Keck Genomics & Proteomics Core

This is a resource for investigators which provides even novice investigators with supported access to the Keck Lab at Yale, a state-of-the-art Affymetrix facility. This collaboration provides investigators with the following benefits:

  • Affymetrix gene expression analysis on state-of-the-art instrumentation
  • SNP genotyping services
  • Biostatistical support
  • A significant discount for Keck Lab service charges