Jonathan M. Siner, MD

Instructor in Medicine (Pulmonary and Critical Care)

1992	BA	Swarthmore College, Swarthmore, PA, Biology
1998	MD	University of Pittsburgh, Pittsburgh, PA, Medicine
1998-2001	Intern/Res	University of Pennsylvania, Philadelphia, PA, Internal Medicine
2002-2006	Fellow	Yale University, New Haven, CT,Pulmonary & Critical Care Medicine

Positions

1998-1999	Intern, Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
1999-2001	Resident, Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
2001-2002	Instructor in Medicine/Academic Hospitalist, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
2002-2006	Postdoctoral Fellow, Pulmonary & Critical Care Medicine, Yale University School of Medicine, New Haven, CT
2006-present	Instructor of Medicine, Pulmonary & Critical Care Medicine, Yale University School of Medicine, New Haven, CT

Honors and Awards

1998	American College of Physicians Senior Award In Medicine
1997	Alpha Omega Alpha Honor Medical Society
1992	Sigma Xi Scientific Research Society

Publications

• Siner J, Paredes A, Hosselet C, Hammond T, Strange K, Harris HW.  Cloning of an auqaporin homologue present in water channel containing endosomes of toad urinary bladder.  American Journal of Physiology, 1996, 270:C372-81.
• Siner JM, Jiang G, Cohen ZI, Shan P, Zhang X, Lee CG, Elias JA, Lee PJ.  VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia.  FASEB Journal (in press).

Research Funding

Ongoing

Angiopoietin-2 in Severe Sepsis

1ULI PRO024139-01 - 4/1/2007 – 9/30/2008
Robert Sherwin M.D. (PI)
NIH/NCRR

This study proposes to examine the relationship between the levels of circulating Angiopoietin-2 upon admission and outcomes in patients with severe sepsis.  The relationship of Angiopoietin-2 to Angiopoietin-1 and Vascular Endothelial Growth Factor will be examined.  The location of production of Angiopoietin-2 will be determined through autopsy examination of septic patients.

Completed

Cytoprotection by VEGF and HO-1 in Acute Lung Injury. 

5 F32-HL078127 - 9/1/04 – 8/31/06
Siner (PI)
NIH-NHLBI

This study examined the role of VEGF-induced heme oxygenase-1 (HO-1) in cytoprotection from hyperoxic acute lung injury in vivo.  The role of VEGF-induced HO-1 was investigated using gene silencing with siRNA in VEGF lung-specific transgenic mice.