Varman T. Samuel, MD, PhD

Assistant Professor of Medicine (Endocrinology) and Lecturer in Molecular Biophysics and Biochemistry

1991	BS Cornell University, College of Agriculture and Life Sciences, Biology
1994	MD New York University School of Medicine
2005	PhD Yale University School of Medicine, Investigative Medicine

Positions

June 1990-August 1991	Research Assistant, Cornell University
June 1992-August 1992	Research Assistant, NYU School of Medicine
July 1995- June 1998	Resident Physician, Internal  Medicine, University of Chicago Hospitals
July 1998- June 2000	Fellow, Section of Endocrinology, University of Chicago Hospitals
July 2000-June 2005	Post Doctoral Associate, Section of Endocrinology
	Graduate Student, Investigative Medicine Program
July 2003-Pres	Attending Physician, VAMC West Haven, Section of Endocrinology
July 2005-Pres	Assistant Professor of Medicine, Yale University School of Medicine

Honors

1991	B.S. in Biology with Honors, Cornell Univeristy
1995	Alpha Omega Alpha, NYU  School of Medicine

Publications

Samuel VT, Liu ZX, Wang A. Beddow SA, Geisler JG, Kahn M, Zhang XM, Bhanot S, Bonia BP, Shulman GI. Inhibition of Protein Kinase C Epsilon With Synthetic Antisense Oligonucleotides Protects Against Fat Induced Hepatic Insulin Resistance.  J Clin Invest 2007 March

Samuel VT, Choi CS, Philips T, Shulman GI, Veniant-Ellison M.  Inhibition of foxo1 improves hepatic insulin sensitivity in mice with diet induced obesity.  Diabetes 2006 July

Savage DB, Choi C, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J. Clin Inves 2006 Feb 16

Bilz S, Samuel V, Mornio K, Savage D, Choi CS, Shulman GI. Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters.  Am J Physiol Endocrinol Metab. 2006 Apr

Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem. 2004 July 30

Chutkow WA, Samuel V, Hansen PA, Pu J, Valdivia CR, Makielski JC, Burant CF. Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle. Proc Natl Acad Sci. 2001 Sep 25;98(20):11760-4.

Yen, A. Samuel, V., Forbes, M. Regulation of cell proliferation: late down-regulation of  c-myb preceding myelo-monocytic cell differentiation.  Journal of Cellular Physiology 153(1):147-56 1992 Oct.

Research Funding

Ongoing

Mechanisms of Fat Induced Hepatic Insulin Resistance

1 K23 RR17404-01
July 2002-July 2007
Agency: NIH/NCRR

This grant investigates the mechanism by which hepatic fat accumulation alters the insulin signaling cascade and leads to hepatic insulin resistance.
Role: PI

Completed

Mechanisms of Fat Induced Hepatic Insulin Resistance

Fellowship Research Training Award
12/2001-12/2002
Agency: Lilly Research Laboratories                  

Determine the cellular mechanisms of fat induced hepatic insulin resistance in a rodent model
Role: PI