Chiang-shan (Ray) Li, MD

Assistant Professor of Psychiatry

1989	M.D.	National Taiwan University, Taipei, Taiwan, Medicine
1996	Ph.D.	California Inst. of Technology, Pasadena, CA, Neuroscience
1996-1998	fellow	Massachusetts Institute of Technology, MA, Neuroscience
1998-2001	resident	Chang Gung Memorial Hospital, Taiwan, Psychiatry
2001-2003	fellow	Yale University, New Haven, CT, Psychiatry

Positions

1988-1989	Medical Intern, National Taiwan University Hospital, Taipei, TAIWAN
1989-1991	Medical Officer (Compulsory Military Service), Taiwan Navy, TAIWAN
1991-1996	McDonald-Pew fellow and Crutcher Fellow, Ph.D. program in Computation and Neural Systems, California Institute of Technology, Pasadena, CA
1996-1998	McDonald-Pew Postdoctoral Fellow, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA
1998-2001	Psychiatry Resident, Department of Psychiatry, Chang Gung Memorial Hospital, Tao-Yuan, TAIWAN. Psychiatry Board Certification (Taiwan)
1998-2001	Associate Researcher (joint appointment), Medical Research Center, Chang Gung Memorial Hospital, Tao-Yuan, TAIWAN
1998-2001	Adjunct Assistant Professor (joint appointment), Department of Physiology, Chang Gung, University, Tao-Yuan, TAIWAN
2003-2005	Associate Research Scientist, Department of Psychiatry, Yale University, New Haven, CT
2004-	BIRWCH Scholar, Department of Psychiatry, Yale University, New Haven, CT
2005-	Assistant Professor, Department of Psychiatry, Yale University, New Haven, CT

Awards

2001-2003

Ruth L. Kirschstein National Research Service Award, Senior Research Fellow, Department of Psychiatry, Yale University and VA Medical Center, CT

Publications

• Li, C.-S. R., Mazzoni, P. & Andersen, R.A. (1999) The effect of reversible inactivation of macaque lateral intraparietal area on visual and memory saccades. Journal of Neurophysiology 81: 1827-1838.
• Li, C-S. R., Chen, M., Yang Y.-Y., Chang, H.-L., Liu, C.-Y., Shen, S. & Chen, C.-Y. (2000) Perceptual alternation in obsessive compulsive disorder-implications for a role of the cortico-striatal circuitry in mediating awareness. Behavioral Brain Research 111: 61-69.
• Gandolfo, F., Li, C.-S. R., Benda, B. J., Padoa Schioppa, C. & Bizzi, E. (2000) Cortical correlates of learning in monkeys adapting to a new dynamical environment. Proceedings of the National Academy of Science (USA) 97: 2259-2263.
• Li, C.-S. R. & Andersen, R.A. (2001) Reversible inactivation of macaque lateral intraparietal area delays the initiation of the second saccades from predominantly contralesional eye positions in a double saccade task. Experimental Brain Research 137: 45-57.
• Li, C-S. R., Padoa-Schioppa, C. & Bizzi, E. (2001) Neural correlates of motor performance and motor learning in monkeys adapting to an external force field. Neuron 30: 593-607.
• Li, C-S. R., Chen, M., Yang, Y.-Y., Chen, M.-C. & Tsay, P.-K. (2002) Altered performance of schizophrenia patients in an auditory detection and discrimination task- exploring the “self-monitoring” model of auditory hallucination. Schizophrenia Research 55: 115-128.  
• Li, C.-S.R. (2002) Impaired detection of visual motion in schizophrenia patients. Progress in Neuropsychopharmacology and Biological Psychiatry 26: 929-934.
• Li, C-S.R. & Lin, S.-C. (2002) A perceptual level mechanism of the inhibition of return in oculomotor planning. Cognitive Brain Research 14: 269-276.
• Li, C-S.R. & Lin, S.-C. (2002) Inhibition of return in temporal order saccades. Vision Research 42: 2089-2093.
• Li, C.-S.R., Lin, W.-H., Yang, Y.-Y., Huang, C.-C., Chen, Y.-C. & Chen, T.-W. (2002) Impairment of temporal attention in schizophrenia patients. NeuroReport 13: 1427-1430.
• Padoa Schioppa, C., Li, C-S. R., & Bizzi, E. (2002) Planning movements: kinematics-to-dynamics transformation in the supplementary motor area. Neuron 36: 751-765.
• Li, C.-S.R., Chang, H.-L. & Lin, S.-C. (2003) Inhibition of return in children with attention deficit hyperactivity disorder. Experimental Brain Research 149: 125-130.
• Li, C.-S.R., Yang, Y.-Y., Chen, M., Chen, W.J. & Liu, R.-L. (2003) Auditory discrimination in female adolescents varying in schizotypal features: preliminary findings. Psychiatry and Clinical Neuroscience 57: 391-397.
• Padoa-Schioppa, C., Li, C-S. R., & Bizzi, E. (2004) Neuronal plasticity in SMA of monkeys adapting to a dynamic force environment. Journal of Neurophysiology 91: 449-473.
• Li, C.-S.R., Lin, W.-H., Chang, H.-L. & Hung, Y.-W. (2004) A psychophysical measure of attention deficit in children with ADHD. Journal of Abnormal Psychology 113: 228-236.
• Li, C.-S.R. (2004) Do schizophrenia patients make more perseverative than non-perseverative errors in Wisconsin Card Sorting Tests? Psychiatry Research 129: 179-190.
• Tseng, Y.-C. & Li, C.-S.R. (2004) Oculomotor correlates of context-guided learning in visual search. Perception and Psychophysics 66: 1363-1378.
• Li, C.-S.R., Chen, S.-H., Lin, W.-H., Yang, Y.-Y. (2005) Attentional blink in adolescents with varying levels of impulsivity. Journal of Psychiatric Research 39: 197-205.
• Li, C.-S.R., Kosten, T.R. & Sinha, R. (2005) Sex differences in brain activation during stress imagery in abstinent cocaine users – a functional magnetic resonance imaging study. Biological Psychiatry 57: 487-494.
• Li, C.-S. R., Kemp K.A., Milivojevic, V. & Sinha, R. (2005) Neuroimaging reveals sex difference in the neuropathology of cocaine abuse. Gender Medicine 2: 174-182.
• Li, C.-S.R., Mathalon, D.H., & Krystal, J.H. (2005) Fore-period effect and stop signal processing time. Experimental Brain Research 167: 305-309.
• Li, C.-S.R., Milivojevic, V., Constable, R. T., & Sinha, R. (2005) Recent cannabis abuse decreases stress-induced BOLD signals in frontal and cingulate cortices of cocaine dependent individuals. Psychiatry Research: Neuroimaging 140: 271-280.
• Li, C.-S.R., Huang, C., Constable, T., & Sinha, R. (2006) Imaging response inhibition in a stop signal task – neural correlates independent of signal monitoring and post-response processing. Journal of Neuroscience 26: 186-192.
• Li, C.-S.R. & Sinha, R. (2006) Alexithymia and stress-induced brain activation in cocaine dependent men and women. Journal of Psychiatry and Neuroscience 31: 115-121. Li, C.-S.R., Kosten, T.R. & Sinha, R. (2006) Antisocial personality and stress-induced brain activation in cocaine dependent individuals. NeuroReport 17: 243-247.
• Li, C.-S.R., Huang, C., Constable, R.T. & Sinha, R. (2006) Gender differences in the neural correlates of response inhibition during a stop signal task. NeuroImage 32: 1918-1929.
• Li, C.-S.R., Chang, H.-L., Hsu, Y.-P., Wang, H.-S. & Ko, N.-C. (2006) Motor response inhibition in children with Tourette’s Disorder. Journal of Neuropsychiatry and Clinical Neuroscience 18: 417-419.
• Li, C.-S.R., Milivojevic, V., Kemp K.A., Hong K. & Sinha, R. (2006) Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug and Alcohol Dependence 85: 205-212.
• Sinha, R., & Li, C.-S.R. (In Press) Imaging stress and cue-induced drug and alcohol craving states: association with relapse and clinical implications. Drug and Alcohol Review.
• Li, C.-S.R. & Chen, S.-H. (In Press) Obsessive-compulsiveness and impulsivity in a non-clinical population of adolescent males and females. Psychiatry Research.
• Li, C.-S.R. & Sinha, R. (In Press) Frontolimbic dysfunctions in patients with cocaine dependence – neuroimaging evidence and a cognitive analytic perspective. Neuroscience and Biobehavioral Reviews.
• Li, C.-S.R., Huang, C.-Y., Lin, W-Y. & Sun V.C.-W. (In Press) Gender differences in punishment and reward sensitivity in a Taiwanese sample of college students. Personality and Individual Differences.  

Research Funding

Ongoing

Yale Interdisciplinary Women’s Health Research Scholar Program on Women and Drug Abuse (BIRWCH)

NIDA/ORWH K12 DA14038 P.I. Carolyn Mazure
Source: NIH Office of Research on Women’s Health and NIDA $456,086/year, direct cost; $36,487/year,
indirect cost
Duration: 09/01/2000-08/31/2005 (extended 06/30/2007) Percent effort: 75%
Role: Scholar

Specialized Center of Research (SCOR) on Women’s Health: Sex, Stress and Cocaine Addiction

NIDA P50-DA16556-01 P.I. Rajita Sinha
Source: NIDA $782,778/year, direct cost; $350,229/year, indirect cost
Duration: 09/30/2002 – 05/31/2007 Percent effort: 25%
Role: Co-Investigator

Imaging inhibitory control in cocaine dependence

NIDA 1R03DA022395-01A1 P.I. Chiang-shan Ray Li
Source: NIDA $150,000/year, direct cost; $68,250, indirect cost
Duration: 09/28/2006-09/27/2007 Percent effort: 50% (Concurrent)
Role: Principal Investigator

Multimodal imaging of cocaine dependence

Yale Clinical Translational Science Award (CTSA)
P.I. Robert Sherwin
Source: NIH $93,859/18 months
Duration: 03/01/2007-08/31/2008
Role: Scholar

Pending

Cognitive control and cocaine dependence

NIDA R01
12/01/2007-11/30/2012 1,250,000 Direct
Role: Principal Investigator

Imaging impulsivity in alcoholism

Alcohol Beverage Medical Research Foundation Research Grant
11/01/2007-10/30/2009 100,000 Direct
Role: Principal Investigator