Jeptha Curtis, MD

Assistant Professor of Medicine (Cardiology)

1993	BA	Yale University	American Studies
1997	MD	Columbia University	Medicine

Positions

1997-2000	Residency, Internal Medicine, Duke University Medical Center, Durham, NC
2000-2003	Fellowship, Cardiovascular Disease, Yale University School of Medicine, New Haven, CT
2003-2004	Fellowship, Interventional Cardiology, Yale University School of Medicine, New Haven, CT
2004-2006	Instructor, Cardiology, Yale University School of Medicine, New Haven, CT
2006-	Assistant Professor, Yale University School of Medicine, New Haven, CT

Publications

• Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. Beta blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA 2002;288:351-357.
• Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM, Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 2003, 289:871-878.
• Curtis JP, Sokol SI, Wang Y, Rathore SS, Jadbabaie F, Portnay EL, Ko DT, Marshalko SM, Radford M, Krumholz HM. The association of LVEF and mortality in stable outpatients with heart failure. J Am Coll Cardiol 2003;42:736-42.
• Abbott JD, Curtis JP, Murad K, Kramer, HM, Remetz MS, Setaro JF, Brennan JJ. Spontaneous coronary dissection in a women receiving 5-FU chemotherapy. Angiology 2003; 54:725-28.
• Curtis JP, Portnay EL, Wang Y, Masoudi FA, Havranek E, Krumholz HM. Aspirin, ibuprofen and mortality after AMI. BMJ 2003;327:1322-1323.
• Curtis JP, Rathore SS, Wang Y, Krumholz HM. The association of 6-minute walk distance and outcomes in stable outpatients with heart failure. J Card Fail 2004;10:9-14.
• Curtis JP, Krumholz HM. The case for an adverse pharmacodynamic interaction between aspirin and NSAIDs: is it time to believe the hype? J Am Coll Cardiol 2004;43:991-993.
• Ko DT, Hebert P, Coffey C, Curtis JP, Foody JM, Sedrakyan A,  Krumholz HM. A quantitative overview of adverse effects of beta-blocker therapy in patients with heart failure. Arch Intern Med 2004;164:1389-1394.
• Vitagliano G, Curtis JP, Concato J, Feinstein AR, Radford MJ, Krumholz HM. Association of functional status with use and effectiveness of beta-blocker prophylaxis in elderly survivors of acute myocardial infarction. J Am Ger Soc 2004; 52:495-501.
• Curtis JP, Alexander J, Huang Y, Wallentin L, Verheugt F, Armstrong P, Krumholz HM, Van de Werf F, Granger C. Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction: Results from ASSENT-2 and ASSENT-3. Am J Cardiol 2004;94:279-283.
• Sokol SI, Portnay EL, Curtis JP, Nelson MA, Hebert PR, Setaro JF, Foody JM. Modulation of the renin angiotensin aldosterone system for the secondary prevention stroke: therapeutic mechanisms and contemporary trial evidence. Neurology 2004;63:208-213.
• Masoudi FM, Rathore SS, Wang Y, Foody JM, Havranek E, Curtis JP, Krumholz HM. National patterns of use of angiotensin-converting enzyme inhibitors in elderly patients admitted with heart failure. Circulation 2004;110:724-731.
• Curtis JP, Ko DT, Wang Y, Khamiees RM, Wackers FJ, Foody JM. The prognostic importance of vasodilator SPECT myocardial perfusion imaging in octogenarians. Am J Geriatr Cardiol 2004;13:239-245.
• Curtis JP, Krumholz HM. Keeping the patient in view: defining the appropriateness of percutaneous coronary interventions. Circulation 2004;110:3744-3745.
• Curtis JP, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F, Portnay EL, Sokol SI, Kosiborod M, Bader F, Krumholz HM. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005;165:55-61.
• Magid DJ. Wang Y. Herrin J. McNamara RL. Bradley EH. Curtis JP. Pollack CV Jr. French WJ. Blaney ME. Krumholz HM. Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction. JAMA 2005;294:803-812.
• Heitner JF. Curtis JP. Haq SA. Corey GR. Newby LK. Jollis JG. The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography. Clin Cardiol. 2005;28:333-336.
• Portnay EL, Foody JM, Rathore SS, Wang Y, Masoudi FA, Curtis JP, Krumholz HM. Prior aspirin use and outcomes in elderly patients hospitalized with acute myocardial infarction. J Am Coll Cardiol 2005;46:967-974.
• Kosiborod M, Curtis JP, Wang Y-F, Smith GL, Masoudi FA, Foody JM, Havranek EP, Krumholz HM. Anemia and outcomes in patients with heart failure: a study from the National Heart Care Project. Arch Intern Med 2005;165:2237-2244.
• Kim N, Gross CP, Curtis JP, Stettin GD, Wogen S, Choe N, Krumholz HM. The impact of clinical trials on the use of hormone replacement therapy: a population-based study. J Gen Intern Med 2005;20:1026-1031.
• McNamara RL, Herrin J, Bradley EH, Portnay EL, Curtis JP, Wang Y-F, Magid DJ, Blaney M, Krumholz HM for the NRMI Investigators. Hospital improvement in time to reperfusion in patients with acute myocardial infarction, 1999-2002. J Am Coll Cardiol 2006;47:45-51.
  
• Curtis JP, Portnay EL, Wang Y-F, McNamara RL, Herrin J, Bradley EH, Magid DJ, Blaney ME, Canto JG, Krumholz HM. The pre-hospital electrocardiogram and time to reperfusion in patients with acute myocardial infarction, 2000-2002. Findings from the National Registry of Myocardial Infarction-4. J Am Coll Cardiol 2006;47:1544-1552.
• Rathore SS, Masoudi FA, Wang Y-F, Curtis JP, Foody JM, Havrenek EP, Krumholz HM. Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: findings from the National Heart Failure Project. Am Heart J 2006;152:371-8.
• McNamara RM, Wang Y-F, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM. Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2006;47:2180-6.
• Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for reducing the door-to-balloon time in acute myocardial infarction. New Engl J Med 2006;355:2308-20.
• Rathore SS, Curtis JP, Krumholz HM. Serum digoxin concentration and the effectiveness of digoxin therapy in the treatment of heart failure: an analysis of the Digitalis Investigation Group (DIG) Trial. Compendium Series: Cardiol (In Press).
• Curtis JP, Cohen DJ, Jones P, Bach RG, Spertus JA, Krumholz HM. Impact of an FDA Public Health Notification on Clinical Practice: Adoption of Drug Eluting Stents in Patients with Acute Coronary Syndromes. Am J Cardiology: In Press.

Research Support

Ongoing

Telemonitoring to Improve Heart Failure Outcomes

R01 HL080228 Krumholz (PI) 7.1.05-6.30.09
National Heart, Lung, and Blood Institute

The aim of this multicenter, randomized controlled trial, in which we plan to recruit 1,640 patients from community-based cardiology practices across the United States, is to examine a telemonitoring strategy that facilitates communication between patients and health care providers and the general education of patients about managing their conditions. Using a telephone system that does not require Internet access, we will determine whether use of this strategy for 6 months, added to usual medical care, reduces rates of all-cause readmission in patients who had been hospitalized for heart failure in the previous 30 days.
Role: Investigator (10% effort)

Pending

Young women with acute myocardial infarction

TBD Krumholz (PI)4.1.07-3.31.12
National Heart, Lung, and Blood Institute $1,514,678

The aims of this proposal are to characterize sex differences in outcomes following AMI (including mortality, hospitalization and health status); determine sex differences in the prevalence of demographic, clinical, and psychosocial risk factors; determine sex differences in quality of care; and determine sex differences in the prevalence of selected biological factors (including sex hormones, biomarkers and genetic variations).
Role: Investigator (10% effort)