Investigative Medicine Program

This highly innovative program awards a PhD degree in Investigative Medicine to physicians training in either laboratory-based or clinically-based patient-oriented research. It has been expanded under the Clinical and Translational Science Award (CTSA) to include scholars in nursing, public health, biomedical engineering, and biological and biomedical sciences who are seeking a PhD with a focus in clinical investigation. IMP also serves as a vehicle for integrating student training; many other individuals (medical, nursing and graduate students, residents, as well as clinical fellows and junior faculty members, some of whom are YCCI Scholars) take courses offered by the IMP each year. 

A total of 40 trainees have matriculated since the IMP began admitting students in July 2000. The program currently admits five to six new students per year. In addition, approximately 250 trainees from other programs and faculty members take IMP courses annually. IMP trainees are typically supported by institutional T32 awards or by institutional funds (necessary for those who are not US citizens or permanent residents) during their first two to three years of training in the IMP, analogous to biomedical science graduate students at Yale. After this, they are generally supported by their own grants or by departmental sources.  Alumni have gone on to academic positions at Yale, Boston University, University of Chicago, Duke NUS Graduate Medical School – Singapore, University of New Mexico, Memorial Sloan-Kettering Cancer Center,  University of Pittsburgh, University of Texas Health Science Center at San Antonio, University of Pennsylvania School of Medicine,  Cleveland Clinic Foundation and Hadassah Hebrew University School of Medicine.

Click here for a list of representative publications.

Current IMP Students

Past IMP Students

IMP trainees must complete at least two years of postgraduate clinical training before entry, typically after completing residency or clinical subspecialty training. The program requires completion of nine semester-length courses, including seven (for trainees in patient-oriented research) or eight (for trainees in laboratory-based research) required subjects from a list of IMP courses: biostatistics, principles of clinical research, cellular and molecular basis of human disease, translational and functional genomics, topics in human investigation [structure-based drug design and moving a new drug to the clinic], grant-writing [K or R proposal], directed reading [intense mentor-directed literature discussion on three thesis-related topics], ethical issues in clinical investigation, and beginning, intermediate, and advanced methods in clinical research. All students are required to take the course on ethics in clinical investigation. Students also complete three graduate-level electives. Students focusing on both patient-oriented and laboratory-based investigation are engaged in the courses simultaneously to enhance integration and to promote broad-based training. When course requirements are met (by month 18 of the program), students submit thesis proposals and take comprehensive oral and written qualifying examinations. Subsequent degree requirements include completing a dissertation project, writing a dissertation, and passing an oral thesis defense.collapse